Identification of Direct Protein Targets of Small Molecules | Zendy

Brett Lomenick | Zendy; Richard W. Olsen | Zendy; Jing Huang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Identification of Direct Protein Targets of Small Molecules

Author(s) -

Brett Lomenick,

Richard W. Olsen,

Jing Huang

Publication year - 2010

Publication title -

acs chemical biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.899

H-Index - 111

eISSN - 1554-8937

pISSN - 1554-8929

DOI - 10.1021/cb100294v

Subject(s) - chemical biology , small molecule , chemical genetics , identification (biology) , proteome , bottleneck , computational biology , drug discovery , systems biology , biology , computer science , nanotechnology , data science , bioinformatics , genetics , materials science , botany , embedded system

Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the power of chemical genetics to impact biology and medicine. To overcome this "target ID" bottleneck, new technologies are being developed that analyze protein-drug interactions, such as drug affinity responsive target stability (DARTS), which aims to discover the direct binding targets (and off targets) of small molecules on a proteome scale without requiring chemical modification of the compound. Here, we review the DARTS method, discuss why it works, and provide new perspectives for future development in this area.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research