Imparting Superhydrophobicity to Biodegradable Poly(lactide-co-glycolide) Electrospun Meshes | Zendy

Jonah A. Kaplan | Zendy; Hongyi Lei | Zendy; Rong Liu | Zendy; Robert F. Padera | Zendy; Yolonda L. Colson | Zendy; Mark W. Grinstaff | Zendy

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Imparting Superhydrophobicity to Biodegradable Poly(lactide-co-glycolide) Electrospun Meshes

Author(s) -

Jonah A. Kaplan,

Hongyi Lei,

Rong Liu,

Robert F. Padera,

Yolonda L. Colson,

Mark W. Grinstaff

Publication year - 2014

Publication title -

biomacromolecules

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.689

H-Index - 220

eISSN - 1526-4602

pISSN - 1525-7797

DOI - 10.1021/bm500410h

Subject(s) - plga , biocompatibility , copolymer , glycolic acid , biodegradable polymer , polymer , materials science , chemical engineering , polylactic acid , polymer chemistry , electrospinning , ethylene glycol , tissue engineering , polyester , lactic acid , chemistry , nanotechnology , nanoparticle , composite material , biomedical engineering , engineering , medicine , biology , bacteria , metallurgy , genetics

The synthesis of a family of new poly(lactic acid-co-glycerol monostearate) (PLA-PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes. Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers. Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) properties. Contact angles as high as 160° are obtained with 30% polymer dopant. Lastly, these meshes are nontoxic, as determined by an NIH/3T3 cell biocompatibility assay, and displayed a minimal foreign body response when implanted in mice. In summary, a general method for constructing biodegradable fibrous meshes with tunable hydrophobicity is described for use in tissue engineering and drug delivery applications.

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