Interactions of 4-nitroquinoline 1-oxide with four deoxyribonucleotides | Zendy

Stephen A. Winkle | Zendy; Ignacio Tinoco | Zendy

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Interactions of 4-nitroquinoline 1-oxide with four deoxyribonucleotides

Author(s) -

Stephen A. Winkle,

Ignacio Tinoco

Publication year - 1978

Publication title -

biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.43

H-Index - 253

eISSN - 1520-4995

pISSN - 0006-2960

DOI - 10.1021/bi00600a033

Subject(s) - altmetrics , citation , computer science , headline , social media , information retrieval , icon , citation database , reuse , world wide web , medline , advertising , chemistry , biology , business , programming language , ecology , biochemistry , scopus

The interactions of 4-nitroquinoline 1-oxide (NQO) with the four 5'-deoxyribonucleotides were probed using absorption spectra of the charge transfer bands and 1H and 13C nuclear magnetic resonance (NMR) spectra of nucleotide-NQO mixtures. Spectral data yielded equilibrium constants (K(dpG:NQO) = 16 M-1, K(dpA:NQO) = 12 M-1, K(dpT:NQO) = K(dpC:NQO) = 4 M-1) which suggest the preference of NQO for the guanine residue in a DNA. This is in agreement with the data of Okano, T., et al. [(1969) Gann 60, 295]. From 13C and 1H NMR data on nucleosides, a structure for the dpG:NQO complex is proposed.

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