Charge Dependence of Ligand Release and Monolayer Stability of Gold Nanoparticles by Biogenic Thiols | Zendy

Apiwat Chompoosor | Zendy; Gang Han | Zendy; Vincent M. Rotello | Zendy

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Charge Dependence of Ligand Release and Monolayer Stability of Gold Nanoparticles by Biogenic Thiols

Author(s) -

Apiwat Chompoosor,

Gang Han,

Vincent M. Rotello

Publication year - 2008

Publication title -

bioconjugate chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.279

H-Index - 172

eISSN - 1520-4812

pISSN - 1043-1802

DOI - 10.1021/bc8000694

Subject(s) - chemistry , colloidal gold , ligand (biochemistry) , surface charge , monolayer , cysteine , thiol , cationic polymerization , nanoparticle , glutathione , combinatorial chemistry , nanotechnology , organic chemistry , biochemistry , receptor , enzyme , materials science

The effect of surface charge on the stability of gold nanoparticles (AuNPs) to the biogenic thiols glutathione (GSH), dihydrolipoic acid (DHLA), and cysteine was quantified. It was observed that the rate of release of fluorescein-tagged ligand was determined by the surface charge of the AuNPs, with cationic particles much more labile than anionic analogues. This ability to tune stability is significant for the design of both delivery vehicles and intracellular probes.

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