In Situ Conjugation of Dithiophenol Maleimide Polymers and Oxytocin for Stable and Reversible Polymer–Peptide Conjugates | Zendy

Jennifer Collins | Zendy; Joji Tanaka | Zendy; Paul Wilson | Zendy; Kristian Kempe | Zendy; Thomas P. Davis | Zendy; Michelle P. McIntosh | Zendy; Michael R. Whittaker | Zendy; David M. Haddleton | Zendy

Open Access

In Situ Conjugation of Dithiophenol Maleimide Polymers and Oxytocin for Stable and Reversible Polymer–Peptide Conjugates

Author(s) -

Jennifer Collins,

Joji Tanaka,

Paul Wilson,

Kristian Kempe,

Thomas P. Davis,

Michelle P. McIntosh,

Michael R. Whittaker,

David M. Haddleton

Publication year - 2015

Publication title -

bioconjugate chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.279

H-Index - 172

eISSN - 1520-4812

pISSN - 1043-1802

DOI - 10.1021/bc5006202

Subject(s) - maleimide , chemistry , conjugate , oxytocin , polymer , in situ , peptide , combinatorial chemistry , disulfide bond , polymer chemistry , organic chemistry , biochemistry , medicine , mathematical analysis , mathematics

The in situ one-pot synthesis of peptide-polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.

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