Upconversion Nanoparticles: A Versatile Solution to Multiscale Biological Imaging | Zendy

Xiang Wu | Zendy; Guanying Chen | Zendy; Jie Shen | Zendy; Zhanjun Li | Zendy; Yuanwei Zhang | Zendy; Gang Han | Zendy

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Upconversion Nanoparticles: A Versatile Solution to Multiscale Biological Imaging

Author(s) -

Xiang Wu,

Guanying Chen,

Jie Shen,

Zhanjun Li,

Yuanwei Zhang,

Gang Han

Publication year - 2014

Publication title -

bioconjugate chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.279

H-Index - 172

eISSN - 1520-4812

pISSN - 1043-1802

DOI - 10.1021/bc5003967

Subject(s) - photon upconversion , nanomaterials , biological imaging , nanotechnology , chemistry , lanthanide , nanoparticle , fluorescence , optical imaging , nanocarriers , fluorescence lifetime imaging microscopy , excitation wavelength , wavelength , optoelectronics , doping , optics , materials science , ion , physics , organic chemistry

Lanthanide-doped photon upconverting nanomaterials are emerging as a new class of imaging contrast agents, providing numerous unprecedented possibilities in the realm of biomedical imaging. Because of their ability to convert long-wavelength near-infrared excitation radiation into shorter-wavelength emissions, these nanomaterials are able to produce assets of low imaging background, large anti-Stokes shift, as well as high optical penetration depth of light for deep tissue optical imaging or light-activated drug release and therapy. The aim of this review is to line up some issues associated with conventional fluorescent probes, and to address the recent advances of upconverting nanoparticles (UCNPs) as a solution to multiscale biological imaging applications.

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