Tumor-Homing Glycol Chitosan-Based Optical/PET Dual Imaging Nanoprobe for Cancer Diagnosis | Zendy

SangMin Lee | Zendy; SunWoong Kang | Zendy; Ju Hee Ryu | Zendy; Jin Hee Na | Zendy; DongEun Lee | Zendy; Seung Jin Han | Zendy; Choong Mo Kang | Zendy; Yearn Seong Choe | Zendy; Kyo Chul Lee | Zendy; James F. Leary | Zendy; Kuiwon Choi | Zendy; Kyung-Han Lee | Zendy; Kwangmeyung Kim | Zendy

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Tumor-Homing Glycol Chitosan-Based Optical/PET Dual Imaging Nanoprobe for Cancer Diagnosis

Author(s) -

SangMin Lee,

SunWoong Kang,

Ju Hee Ryu,

Jin Hee Na,

DongEun Lee,

Seung Jin Han,

Choong Mo Kang,

Yearn Seong Choe,

Kyo Chul Lee,

James F. Leary,

Kuiwon Choi,

Kyung-Han Lee,

Kwangmeyung Kim

Publication year - 2014

Publication title -

bioconjugate chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.279

H-Index - 172

eISSN - 1520-4812

pISSN - 1043-1802

DOI - 10.1021/bc500020g

Subject(s) - nanoprobe , chemistry , positron emission tomography , molecular imaging , biodistribution , azide , click chemistry , optical imaging , imaging agent , magnetic resonance imaging , nanoparticle , nanotechnology , combinatorial chemistry , nuclear medicine , radiology , materials science , optics , biochemistry , medicine , physics , microbiology and biotechnology , organic chemistry , in vivo , in vitro , biology

Imaging techniques including computed tomography, magnetic resonance imaging, and positron emission tomography (PET) offer many potential benefits to diagnosis and treatment of cancers. Each method has its own strong and weak points. Therefore, multimodal imaging techniques have been highlighted as an alternative method for overcoming the limitations of each respective imaging method. In this study, we fabricated PET/optical activatable imaging probe based on glycol chitosan nanoparticles (CNPs) for multimodal imaging. To prepare the dual PET/optical probes based on CNPs, both (64)Cu radiolabeled DOTA complex and activatable matrix metalloproteinase (MMP)-sensitive peptide were chemically conjugated onto azide-functionalized CNPs via bio-orthogonal click chemistry, which was a reaction between azide group and dibenzyl cyclooctyne. The PET/optical activatable imaging probes were visualized by PET and optical imaging system. Biodistribution of probes and activity of MMP were successfully measured in tumor-bearing mice.

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