Glycan-Functionalized Fluorescent Chitin Nanocrystals for Biorecognition Applications | Zendy

Juan Zhou | Zendy; Núria Butchosa | Zendy; H. Surangi N. Jayawardena | Zendy; Qi Zhou | Zendy; Mingdi Yan | Zendy; Olof Ramström | Zendy

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Glycan-Functionalized Fluorescent Chitin Nanocrystals for Biorecognition Applications

Author(s) -

Juan Zhou,

Núria Butchosa,

H. Surangi N. Jayawardena,

Qi Zhou,

Mingdi Yan,

Olof Ramström

Publication year - 2014

Publication title -

bioconjugate chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.279

H-Index - 172

eISSN - 1520-4812

pISSN - 1043-1802

DOI - 10.1021/bc500004c

Subject(s) - chemistry , chitin , glycan , fluorescence , nanocrystal , nanotechnology , nanomaterials , conjugated system , bioconjugation , polymer , carbohydrate , chitosan , biophysics , combinatorial chemistry , biochemistry , organic chemistry , glycoprotein , physics , materials science , quantum mechanics , biology

A new platform based on chitin nanocrystals has been developed for biorecognition applications. TEMPO-oxidized chitin nanocrystals (TCNs) were labeled with a fluorescent imidazoisoquinolinone dye, and simultaneously conjugated with carbohydrate ligands, resulting in dually functionalized TCNs. The biorecognition properties of the nanocrystals were probed with lectins and bacteria, resulting in selective interactions with their corresponding cognate carbohydrate-binding proteins, as visualized by optical, fluorescence, STEM, and TEM imaging. This represents a new approach to multifunctional nanomaterials based on naturally occurring polymers, holding high potential for biomedical applications.

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