Synthesis and Functionalization of a Mesoporous Silica Nanoparticle Based on the Sol–Gel Process and Applications in Controlled Release | Zendy

Brian G. Trewyn | Zendy; Igor I. Slowing | Zendy; Supratim Giri | Zendy; HungTing Chen | Zendy; Victor S.Y. Lin | Zendy

Open Access

Synthesis and Functionalization of a Mesoporous Silica Nanoparticle Based on the Sol–Gel Process and Applications in Controlled Release

Author(s) -

Brian G. Trewyn,

Igor I. Slowing,

Supratim Giri,

HungTing Chen,

Victor S.Y. Lin

Publication year - 2007

Publication title -

accounts of chemical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.454

H-Index - 395

eISSN - 1520-4898

pISSN - 0001-4842

DOI - 10.1021/ar600032u

Subject(s) - mesoporous silica , biocompatibility , surface modification , nanomaterials , nanoparticle , nanotechnology , mesoporous material , materials science , porosity , chemical engineering , chemistry , organic chemistry , catalysis , engineering , metallurgy , composite material

Mesoporous silica nanoparticles (MSNs) are introduced as chemically and thermally stable nanomaterials with well-defined and controllable morphology and porosity. It is shown that these particles possess external and internal surfaces that can be selectively functionalized with multiple organic and inorganic groups. On the basis of these characteristics, the biocompatibility of silica, and their efficient uptake by mammalian cells, MSNs are proposed as the basis of nanodevices for the controlled release of drugs and genes into living cells.

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