Characterization of Nucleic Acids by Nanopore Analysis | Zendy

David W. Deamer | Zendy; Daniel Branton | Zendy

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Characterization of Nucleic Acids by Nanopore Analysis

Author(s) -

David W. Deamer,

Daniel Branton

Publication year - 2002

Publication title -

accounts of chemical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 8.454

H-Index - 395

eISSN - 1520-4898

pISSN - 0001-4842

DOI - 10.1021/ar000138m

Subject(s) - nanopore , nucleic acid , nanoscopic scale , molecule , ionic bonding , chemistry , dna , rna , biophysics , nanotechnology , electric field , blockade , chemical physics , characterization (materials science) , materials science , ion , biochemistry , physics , organic chemistry , biology , gene , receptor , quantum mechanics

Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade.

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