Genetic Constructor: An Online DNA Design Platform | Zendy

Maxwell Bates | Zendy; Joe Lachoff | Zendy; Duncan Meech | Zendy; Valentin Zulkower | Zendy; Anäis Moisy | Zendy; Yisha Luo | Zendy; Hille Tekotte | Zendy; Cornelia Johanna Franziska Scheitz | Zendy; Rupal Khilari | Zendy; Florencio Mazzoldi | Zendy; Deepak Chandran | Zendy; Eli S. Groban | Zendy

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Genetic Constructor: An Online DNA Design Platform

Author(s) -

Maxwell Bates,

Joe Lachoff,

Duncan Meech,

Valentin Zulkower,

Anäis Moisy,

Yisha Luo,

Hille Tekotte,

Cornelia Johanna Franziska Scheitz,

Rupal Khilari,

Florencio Mazzoldi,

Deepak Chandran,

Eli S. Groban

Publication year - 2017

Publication title -

acs synthetic biology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.156

H-Index - 66

ISSN - 2161-5063

DOI - 10.1021/acssynbio.7b00236

Subject(s) - computer science , leverage (statistics) , plug in , software engineering , software , iterative design , computer aided design , architecture , cloud computing , programming language , human–computer interaction , world wide web , artificial intelligence , engineering , operating system , compatibility (geochemistry) , chemical engineering , art , visual arts

Genetic Constructor is a cloud Computer Aided Design (CAD) application developed to support synthetic biologists from design intent through DNA fabrication and experiment iteration. The platform allows users to design, manage, and navigate complex DNA constructs and libraries, using a new visual language that focuses on functional parts abstracted from sequence. Features like combinatorial libraries and automated primer design allow the user to separate design from construction by focusing on functional intent, and design constraints aid iterative refinement of designs. A plugin architecture enables contributions from scientists and coders to leverage existing powerful software and connect to DNA foundries. The software is easily accessible and platform agnostic, free for academics, and available in an open-source community edition. Genetic Constructor seeks to democratize DNA design, manufacture, and access to tools and services from the synthetic biology community.

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