Aerolysin, a Powerful Protein Sensor for Fundamental Studies and Development of Upcoming Applications | Zendy

Benjamin Cressiot | Zendy; Hadjer Ouldali | Zendy; Manuela PastorizaGallego | Zendy; Laurent Bacri | Zendy; Gijs R. van den Brink | Zendy; Juan Pelta | Zendy

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Aerolysin, a Powerful Protein Sensor for Fundamental Studies and Development of Upcoming Applications

Author(s) -

Benjamin Cressiot,

Hadjer Ouldali,

Manuela PastorizaGallego,

Laurent Bacri,

Gijs R. van den Brink,

Juan Pelta

Publication year - 2019

Publication title -

acs sensors

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.055

H-Index - 57

ISSN - 2379-3694

DOI - 10.1021/acssensors.8b01636

Subject(s) - aerolysin , nanopore , biomolecule , nanotechnology , oligonucleotide , folding (dsp implementation) , characterization (materials science) , computational biology , chemistry , molecular biophysics , biophysics , biochemical engineering , biological system , materials science , dna , biology , engineering , biochemistry , virulence , electrical engineering , gene

The nanopore electrical approach is a breakthrough in single molecular level detection of particles as small as ions, and complex as biomolecules. This technique can be used for molecule analysis and characterization as well as for the understanding of confined medium dynamics in chemical or biological reactions. Altogether, the information obtained from these kinds of experiments will allow us to address challenges in a variety of biological fields. The sensing, design, and manufacture of nanopores is crucial to realize these objectives. For some time now, aerolysin, a pore forming toxin, and its mutants have shown high potential in real time analytical chemistry, size discrimination of neutral polymers, oligosaccharides, oligonucleotides and peptides at monomeric resolution, sequence identification, chemical modification on DNA, potential biomarkers detection, and protein folding analysis. This review focuses on the results obtained with aerolysin nanopores on the fields of chemistry, biology, physics, and biotechnology. We discuss and compare as well the results obtained with other protein channel sensors.

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