Achilles’ Heel of SARS-CoV-2 Structure | Zendy

Ariel Fernández | Zendy

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Achilles’ Heel of SARS-CoV-2 Structure

Author(s) -

Ariel Fernández

Publication year - 2020

Publication title -

acs pharmacology and translational science

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.271

H-Index - 10

ISSN - 2575-9108

DOI - 10.1021/acsptsci.0c00128

Subject(s) - heel , protein quaternary structure , infectivity , epitope , covid-19 , virology , antibody , spike protein , coronavirus , virus , protein structure , chemistry , biology , microbiology and biotechnology , medicine , immunology , biochemistry , anatomy , outbreak , protein subunit , disease , infectious disease (medical specialty) , gene

Guided by evolutionarily signaled vulnerabilities in the structure of SARS-CoV-2, we identify epitopes in free monomers of the spike protein that steer the generation of induced or administered antibodies geared at promoting destabilization of the virus quaternary structure, thereby hampering infectivity.

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