Can SARS-CoV-2 Accumulate Mutations in the S-Protein to Increase Pathogenicity? | Zendy

Aditya K. Padhi | Zendy; Timir Tripathi | Zendy

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Can SARS-CoV-2 Accumulate Mutations in the S-Protein to Increase Pathogenicity?

Author(s) -

Aditya K. Padhi,

Timir Tripathi

Publication year - 2020

Publication title -

acs pharmacology and translational science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.271

H-Index - 10

ISSN - 2575-9108

DOI - 10.1021/acsptsci.0c00113

Subject(s) - pathogenicity , infectivity , mutation , biology , virology , covid-19 , virus , pandemic , spike protein , coronavirus , genetics , gene , microbiology and biotechnology , medicine , infectious disease (medical specialty) , disease , pathology

SARS-CoV-2 has developed a substantial number of mutations, especially in the S-protein. With the advancement of the pandemic, accumulations of further mutations at the S-protein receptor-binding domain could enhance the infectivity and pathogenicity of the virus. Prediction and evaluation of such mutations are essential for understanding the potential development of more pathogenic strains and for COVID-19 management.

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