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An atom-economical and environmentally benign approach for the synthesis of indole-substituted 1,4-naphthoquinones from indoles and 1,4-naphthoquinones using readily available Lewis acidic B(C 6 F 5 ) 3 in water and with the recycling of water and part of the catalyst is reported. The reaction proceeded through the B(C 6 F 5 ) 3 -catalyzed C(sp 2 )-H and C(sp 2 )-H bond coupling of 1,4-naphthoquinones with the C-3 position of indole derivatives in water. This methodology provides a facile protocol for the synthesis of some new indole-substituted 1,4-naphthoquinones in satisfactory yields and with a broad substrate scope. When compared to known methods for the synthesis of indole-substituted 1,4-naphthoquinones, this protocol is practical and efficient and does not require a transition-metal catalyst or toxic organic solvents. In addition, we utilized a simple filtration process for complete recycling of the solvent and the part of the catalyst in each reaction cycle.

B(C6F5)3-Catalyzed C–C Coupling of 1,4-Naphthoquinones with the C-3 Position of Indole Derivatives in Water

B(C₆F₅)₃-Catalyzed C–C Coupling of 1,4-Naphthoquinones with the C-3 Position of Indole Derivatives in Water