Facile Hydrogenative Deprotection ofN-Benzyl Groups Using a Mixed Catalyst of Palladium and Niobic Acid-on-Carbon | Zendy

Yuta Yamamoto | Zendy; Eisho Shimizu | Zendy; Kazuho Ban | Zendy; Yoshiyuki Wada | Zendy; Tomoteru Mizusaki | Zendy; Masatoshi Yoshimura | Zendy; Yukio Takagi | Zendy; Yoshinari Sawama | Zendy; Hironao Sajiki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Facile Hydrogenative Deprotection ofN-Benzyl Groups Using a Mixed Catalyst of Palladium and Niobic Acid-on-Carbon

Author(s) -

Yuta Yamamoto,

Eisho Shimizu,

Kazuho Ban,

Yoshiyuki Wada,

Tomoteru Mizusaki,

Masatoshi Yoshimura,

Yukio Takagi,

Yoshinari Sawama,

Hironao Sajiki

Publication year - 2020

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b03226

Subject(s) - catalysis , palladium , chemistry , carbon fibers , organic chemistry , heterogeneous catalysis , activated carbon , materials science , composite number , adsorption , composite material

The palladium-on-carbon (Pd/C)-catalyzed hydrogenative deprotection of the N -benzyl-protecting group was effectively facilitated by the combined use of niobic acid-on-carbon (Nb 2 O 5 /C). Nb 2 O 5 /C is an acidic heterogeneous catalyst prepared from NbCl 5 and activated carbon. The catalysts were easily removed from the reaction mixture and reusable. Deprotected amines were obtained in excellent yields without an additional neutralization process. The facilitating effect of Nb 2 O 5 /C was also observed during the Pd/C-catalyzed hydrogenative deprotection of the N -benzyloxycarbonyl (Cbz) and O -benzyl groups.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research