Optimizing Nanohydroxyapatite Nanocomposites for Bone Tissue Engineering | Zendy

Baboucarr Lowe | Zendy; John G. Hardy | Zendy; Laurence J. Walsh | Zendy

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Optimizing Nanohydroxyapatite Nanocomposites for Bone Tissue Engineering

Author(s) -

Baboucarr Lowe,

John G. Hardy,

Laurence J. Walsh

Publication year - 2019

Publication title -

acs omega

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b02917

Subject(s) - biocompatibility , tissue engineering , materials science , bone healing , nanocomposite , nanotechnology , regeneration (biology) , bone tissue , nanoparticle , biomedical engineering , engineering , anatomy , medicine , biology , microbiology and biotechnology , metallurgy

Bone tissue engineering involves the combined use of materials with functional properties to regenerate bone. Nanohydroxyapatite (nHA) can influence the behavior of cells. The functional and structural properties of nHA can be controlled during nanoparticle synthesis. This review defines the relationship between the attributes of nHA nanoparticles and their biological effects, focusing on biocompatibility, surface-area-to-volume ratio, bonding chemistry, and substrate functionality. The paper explores how these aspects have been applied in the development of scaffolds for the repair of damaged bone or regeneration of missing bone.

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