Imidazolium-Linked Azido-Functionalized Guerbet Glycosides: Multifunctional Surfactants for Biofunctionalization of Vesicles | Zendy

Ean Wai Goh | Zendy; Thorsten Heidelberg | Zendy; Rusnah Syahila Duali Hussen | Zendy; Abbas Abdulameer Salman | Zendy

Open Access

Imidazolium-Linked Azido-Functionalized Guerbet Glycosides: Multifunctional Surfactants for Biofunctionalization of Vesicles

Author(s) -

Ean Wai Goh,

Thorsten Heidelberg,

Rusnah Syahila Duali Hussen,

Abbas Abdulameer Salman

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b02809

Subject(s) - bioconjugation , vesicle , glycolipid , cationic polymerization , click chemistry , drug delivery , combinatorial chemistry , cycloaddition , chemistry , surface modification , biophysics , nanotechnology , materials science , organic chemistry , membrane , catalysis , biochemistry , biology

Aiming for glycolipid-based vesicles for targeted drug delivery, cationic Guerbet glycosides with spacered click functionality were designed and synthesized. The cationic charge promoted the distribution of the glycolipids during the formulation, thereby leading to homogeneously small vesicles. The positive surface charge of the vesicles stabilizes them against unwanted fusion and promotes interactions of the drug carriers with typical negative charge-dominated target cells. High bioconjugation potential of the functionalized glycolipids based on the copper-catalyzed azide alkyne cycloaddition makes them highly valuable components for targeted drug delivery systems.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research