Reinforcement of Polycaprolactone/Chitosan with Nanoclay and Controlled Release of Curcumin for Wound Dressing | Zendy

Yanping Huang | Zendy; Nianhua Dan | Zendy; Weihua Dan | Zendy; Weifeng Zhao | Zendy

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Reinforcement of Polycaprolactone/Chitosan with Nanoclay and Controlled Release of Curcumin for Wound Dressing

Author(s) -

Yanping Huang,

Nianhua Dan,

Weihua Dan,

Weifeng Zhao

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b02217

Subject(s) - thermogravimetric analysis , polycaprolactone , materials science , composite number , biocompatibility , chitosan , contact angle , differential scanning calorimetry , scanning electron microscope , attenuated total reflection , composite material , curcumin , ultimate tensile strength , fourier transform infrared spectroscopy , nuclear chemistry , chemical engineering , chemistry , polymer , biochemistry , physics , engineering , metallurgy , thermodynamics

A novel clay-reinforced polycaprolactone/chitosan/curcumin (PCl/CS/Clay/Cur) composite film was fabricated in this study. The prepared Cur-loading composite films were characterized with attenuated total reflection Fourier transformed infrared spectroscopy, scanning electron microscopy, atomic force microscopy, water contact angle, differential scanning calorimetry, thermogravimetric analysis, and X-ray diffraction, and the results showed good dispersion of clay in the composite films. The addition of nanoclay was found to significantly increase the tensile strength. Also, the clay-enhanced drug-loading films exhibited better controlled-release profiles of Cur than those membranes without clay. Skin disinfection test demonstrated that the curcumin-loaded film could protect wound from bacterial infection. Cytotoxicity analysis proved the good biocompatibility of the composite films. The clay-enhanced Cur-loading films might be promising candidates for wound care.

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