Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells | Zendy

Norah J. Alghamdi | Zendy; Lakshmi Balaraman | Zendy; Kylin A. Emhoff | Zendy; Ahmed M. Salem | Zendy; Ruhan Wei | Zendy; Aimin Zhou | Zendy; W. Christopher Boyd | Zendy

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Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells

Author(s) -

Norah J. Alghamdi,

Lakshmi Balaraman,

Kylin A. Emhoff,

Ahmed M. Salem,

Ruhan Wei,

Aimin Zhou,

W. Christopher Boyd

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b01684

Subject(s) - apoptosis , cobalt , chemistry , cleavage (geology) , poly adp ribose polymerase , nitrosobenzene , ligand (biochemistry) , polymerase , microbiology and biotechnology , stereochemistry , biochemistry , biology , enzyme , receptor , inorganic chemistry , paleontology , fracture (geology) , catalysis

The cobalt(II) complex salts [Co(bpy)(az) 2 ](PF 6 ) 2 and [Co(az) 4 ](PF 6 ), each bearing the unusual cis - N , N '-diphenylazodioxide ligand, were both screened as possible anticancer agents against SK-HEP-1 liver cancer cells. Both compounds were found to induce substantial apoptosis as an increasing function of concentration and time. Measurement of apoptosis-related proteins indicated that both the extrinsic and intrinsic pathways of apoptosis were activated. The apoptotic activity induced by these salts is not displayed either by simple cobalt(II) salts or complexes or by the free nitrosobenzene ligand. Additionally, these compounds did not induce apoptosis, as assessed by poly(adenosine diphosphate-ribose) polymerase cleavage, in several other cell lines.

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