Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp2)–C(sp3) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones | Zendy

Hamada Mohamed Ibrahim | Zendy; Haider Behbehani | Zendy

Open Access

Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp²)–C(sp³) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones

Author(s) -

Hamada Mohamed Ibrahim,

Haider Behbehani

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b01650

Subject(s) - catalysis , atom economy , chemistry , pyridine , combinatorial chemistry , substrate (aquarium) , aryl , pyrazolone , coupling reaction , metal , organic chemistry , medicinal chemistry , oceanography , alkyl , geology

A novel, metal catalyst-free, and efficient method has been developed for the synthesis of (pyrazol-4-ylidene)pyridine derivatives. The process involves dehydrogenative coupling of 1-amino-2-imino-pyridines with 1-aryl-5-pyrazolone derivatives utilizing O 2 as the sole oxidant. The new method benefits from a high atom economy, efficiency, and substrate scope, as well as the simplicity of reaction and product purification procedures.

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