Catalyst- and Solvent-Free Coupling of 2-Methyl Quinazolinones and Isatins: An Environmentally Benign Access of Diastereoselective Schizocommunin Analogues | Zendy

Bhanwar Kumar Malviya | Zendy; Karandeep Singh | Zendy; Pradeep Jaiswal | Zendy; Monika Shukla | Zendy; Ved Prakash Verma | Zendy; Murugesan Vanangamudi | Zendy; Amanpreet Kaur Jassal | Zendy; Pinki B. Punjabi | Zendy; Siddharth Sharma | Zendy

Open Access

Catalyst- and Solvent-Free Coupling of 2-Methyl Quinazolinones and Isatins: An Environmentally Benign Access of Diastereoselective Schizocommunin Analogues

Author(s) -

Bhanwar Kumar Malviya,

Karandeep Singh,

Pradeep Jaiswal,

Monika Shukla,

Ved Prakash Verma,

Murugesan Vanangamudi,

Amanpreet Kaur Jassal,

Pinki B. Punjabi,

Siddharth Sharma

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b01514

Subject(s) - isatin , catalysis , in silico , combinatorial chemistry , chemistry , cytotoxicity , solvent , organic chemistry , biochemistry , in vitro , gene

An environmentally benign highly atom-economic protocol for the construction of the C-C bond has been developed under catalyst- and solvent-free conditions. This protocol involves the efficient coupling of 2-methyl quinazolinones with isatin for the highly diastereoselective access of schizocommunin derivatives in excellent yields (up to 97%). Furthermore, the preliminary cytotoxicity screening of selected schizocommunin analogues displayed promising anticancer activity against human cancer cell lines, and the cytotoxic potential of active compound 12ac was also validated by in silico molecular docking simulation studies.

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