Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles | Zendy

Prantika Bhattacharjee | Zendy; Utpal Bora | Zendy

Open Access

Molecular Iodine-Catalyzed Selective C-3 Benzylation of Indoles with Benzylic Alcohols: A Greener Approach toward Benzylated Indoles

Author(s) -

Prantika Bhattacharjee,

Utpal Bora

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b01481

Subject(s) - catalysis , chemistry , iodine , halogen , ligand (biochemistry) , organic chemistry , combinatorial chemistry , base (topology) , mathematical analysis , biochemistry , alkyl , receptor , mathematics

Iodine-catalyzed selective C-3 benzylation of indoles with benzylic alcohols is developed. The reaction proceeds with molecular iodine as the catalyst under ligand-, metal-, and base-free conditions and tolerates wide functionalities. The experimental observations account for the halogen-bond activation mechanistic pathway for the molecular iodine catalysis.

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