Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I | Zendy

Qihui Shen | Zendy; Man Liu | Zendy; Yang Lü | Zendy; Dawei Zhang | Zendy; Zhenyu Cheng | Zendy; Yan Liu | Zendy; Huajing Gao | Zendy; Zhaohui Jin | Zendy

Open Access

Label-Free Electrochemical Immunosensor Based on a Functionalized Ionic Liquid and Helical Carbon Nanotubes for the Determination of Cardiac Troponin I

Author(s) -

Qihui Shen,

Man Liu,

Yang Lü,

Dawei Zhang,

Zhenyu Cheng,

Yan Liu,

Huajing Gao,

Zhaohui Jin

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b01152

Subject(s) - ionic liquid , carbon nanotube , detection limit , electrochemistry , materials science , linear range , reproducibility , chromatography , analytical chemistry (journal) , chemistry , nanotechnology , electrode , organic chemistry , catalysis

A label-free electrochemical immunosensor for cardiac troponin I was prepared by using a helical carbon nanotube-supported aldehyde-functionalized ionic liquid. Because of the good conductivity of ionic liquid and helical carbon nanotubes, high sensitivity of the immunosensor was obtained. Functionalized ionic liquid provided binding sites for antibody, which simplified the process of sensor construction. Cardiac troponin I was detected by this immunosensor with a linear range of 0.05-30 ng/mL and a detection limit of 0.03 ng/mL. The electrochemical immunosensor had satisfactory reproducibility, high sensitivity, and acceptable specificity.

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