Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines | Zendy

Chao Sun | Zendy; Wubing Yao | Zendy; Xu Chen | Zendy; Yiwen Zhao | Zendy; Qiqi Wei | Zendy; Zishuang Chen | Zendy; Jiashou Wu | Zendy; Feiyue Hao | Zendy; Huiping Xie | Zendy

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Environmentally Benign, Base-Promoted Selective Amination of Polyhalogenated Pyridines

Author(s) -

Chao Sun,

Wubing Yao,

Xu Chen,

Yiwen Zhao,

Qiqi Wei,

Zishuang Chen,

Jiashou Wu,

Feiyue Hao,

Huiping Xie

Publication year - 2019

Publication title -

acs omega

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b01031

Subject(s) - amination , chemistry , dimethylamine , pyridine , solvent , base (topology) , environmentally friendly , dimethylformamide , organic chemistry , combinatorial chemistry , catalysis , mathematical analysis , ecology , mathematics , biology

An environmentally benign, highly efficient, and base-promoted selective amination of various polyhalogenated pyridines including the challenging pyridine chlorides to 2-aminopyridine derivatives using water as solvent has been developed. Featuring the use of the new method, the reaction is extended to the transformation on a large scale. Mechanistic studies indicate that the pathway involving a base aidant dissociation of N , N -dimethylformamide to generate dimethylamine is likely.

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