Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry | Zendy

Vadivel Vaithiyanathan | Zendy; Ravichandran Ganesan | Zendy; Vishnu Kannaiyan | Zendy; Ezhumalai Vellikannu | Zendy; Vijayakumar Thirumailavan | Zendy

Open Access

Synthesis of Substituted Isatins from the MBH Adduct of 1,5,6-Trisubstituted Isatins Using (2,4-Dinitrophenyl)hydrazine and K-10 Clay Explored as Protection–Deprotection Chemistry

Author(s) -

Vadivel Vaithiyanathan,

Ravichandran Ganesan,

Vishnu Kannaiyan,

Ezhumalai Vellikannu,

Vijayakumar Thirumailavan

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b01002

Subject(s) - isatin , adduct , chemistry , phenylhydrazine , hydrazine (antidepressant) , cleavage (geology) , molecule , bond cleavage , organic chemistry , medicinal chemistry , stereochemistry , combinatorial chemistry , catalysis , chromatography , geotechnical engineering , fracture (geology) , engineering

An interesting synthetic transformation of protection-deprotection chemistry in an isatin molecule is achieved. Morita-Baylis-Hillman (MBH) adduct formation used as protection of the C-3 position in the isatin molecule is reported. C-C bond cleavage in the MBH adduct of isatin with the help of phenylhydrazine and C=N bond cleavage in the phenylhydrazone derivative of isatin with the help of K10 clay are studied systematically and reported as deprotection.

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