Highly Sensitive Dansyl-Based Chemosensor for Detection of Cu2+ in Aqueous Solution and Zebrafish | Zendy

Ju Byeong Chae | Zendy; Dongju Yun | Zendy; Hangyul Lee | Zendy; Hyojin Lee | Zendy; KiTae Kim | Zendy; Cheal Kim | Zendy

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Highly Sensitive Dansyl-Based Chemosensor for Detection of Cu²⁺ in Aqueous Solution and Zebrafish

Author(s) -

Ju Byeong Chae,

Dongju Yun,

Hangyul Lee,

Hyojin Lee,

KiTae Kim,

Cheal Kim

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b00970

Subject(s) - aqueous solution , chemistry , zebrafish , fluorescence , chromatography , combinatorial chemistry , nuclear chemistry , organic chemistry , biochemistry , physics , quantum mechanics , gene

A new dansyl-based chemosensor (2-(4-((5-(dimethylamino)naphthalen-1-yl)sulfonyl)piperazin-1-yl)- N -(quinolin-8-yl)acetamide) ( DC) for detecting Cu 2+ was synthesized and characterized. DC showed great selectivity to Cu 2+ by a fluorescent "on-off" detection method. Job plot, ESI-mass spectroscopy, and 1 H NMR titration suggested a 1 to 1 binding mode between DC and Cu 2+ . The detection limit was determined to be 43 nM, which is greatly below the WHO guidelines. In addition, DC can be applied to real samples and zebrafish imaging. The fluorescence quenching mechanism was proposed as the enhancement of intramolecular charge transfer with calculations.

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