Open AccessDirect Amination of Arenes with Azodicarboxylates Catalyzed by Bisulfate Salt/HFIP Association
Author(s) -
RenJin Tang,
Pascal Retailleau,
Thierry Milcent,
Benoı̂t Crousse
Publication year - 2019
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.9b00781
Subject(s) - amination , chemistry , salt (chemistry) , catalysis , organic chemistry , potassium , combinatorial chemistry
A mild and efficient amination of arenes with azodicarboxylates using potassium bisulfate (KHSO 4 ) as the catalyst in 1,1,1,3,3,3-hexafluoro-2-propanol has been developed. This protocol allowed the amination of a broad range of arenes leading to corresponding hydrazides in good to excellent yields.
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