In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer | Zendy

Shilpa Sharma | Zendy; Mohammad Faiyaz Anwar | Zendy; Amit Kumar Dinda | Zendy; Maneesh Singhal | Zendy; Amita Malik | Zendy

Open Access

In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu-Incorporated Polyaspartic and Polyacrylic Acid Superabsorbent Polymer

Author(s) -

Shilpa Sharma,

Mohammad Faiyaz Anwar,

Amit Kumar Dinda,

Maneesh Singhal,

Amita Malik

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b00655

Subject(s) - polyaspartic acid , in vivo , superabsorbent polymer , acrylic acid , polymer , chemistry , polyacrylic acid , in vitro , nuclear chemistry , chromatography , biochemistry , organic chemistry , raw material , microbiology and biotechnology , biology , monomer

The main aim of this study was to evaluate the in vitro and in vivo efficiency of the polyaspartic acid- and acrylic acid-based superabsorbent polymer. The synthesized polymer was first investigated to check the blood compatibility by protein adsorption and blood clotting tests. Further, the GHK-Cu peptide was incorporated within the polymer and release studies were performed to evaluate the drug-delivery efficiency of the superabsorbent polymer. The polymer with best peptide release results were further used for in vivo analysis for wound healing. The healing efficiency of polymer with and without peptide was analyzed using wound closure, biochemical assay, histopathological, and toxicity studies.

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