Solubility Studies of Cyclosporine Using Ionic Liquids | Zendy

Paula Bertón | Zendy; Manish Kumar Mishra | Zendy; Hemant Choudhary | Zendy; Allan S. Myerson | Zendy; Robin D. Rogers | Zendy

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Solubility Studies of Cyclosporine Using Ionic Liquids

Author(s) -

Paula Bertón,

Manish Kumar Mishra,

Hemant Choudhary,

Allan S. Myerson,

Robin D. Rogers

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b00603

Subject(s) - solubility , ionic liquid , acetone , solvent , chemistry , ethyl acetate , amorphous solid , boiling , organic solvent , chromatography , aqueous solution , organic chemistry , nuclear chemistry , chemical engineering , engineering , catalysis

Six ionic liquids (ILs) were selected based on their chemical and physical properties to study the solubility of cyclosporine A. Of these, cyclosporine exhibited higher room temperature solubility in 1-ethyl-3-methylimidazolium acetate ([C 2 mim][OAc]) than in acetone, an effective molecular solvent used to solubilize and purify cyclosporine. The solubility of cyclosporine in the ILs dramatically increased at higher temperatures, a critical factor that cannot be varied in a wide range with low boiling molecular solvents. The differences in solubility were explored for cyclosporine purification. Cyclosporine was purified up to ∼93% with n -butylammonium acetate ([C 4 NH 3 ][OAc]) and could be further purified to 95% using an IL/organic solvent biphasic system. After purification, cyclosporine was recovered as an amorphous solid using the ILs.

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