Biocatalytic Synthesis of Non-Natural Monoterpene O-Glycosides Exhibiting Superior Antibacterial and Antinematodal Properties | Zendy

Puspalata Bashyal | Zendy; Ramesh Prasad Pandey | Zendy; Samir Bahadur Thapa | Zendy; Min-Kyoung Kang | Zendy; ChangJin Kim | Zendy; Jae Kyung Sohng | Zendy

Open Access

Biocatalytic Synthesis of Non-Natural Monoterpene O-Glycosides Exhibiting Superior Antibacterial and Antinematodal Properties

Author(s) -

Puspalata Bashyal,

Ramesh Prasad Pandey,

Samir Bahadur Thapa,

Min-Kyoung Kang,

ChangJin Kim,

Jae Kyung Sohng

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.9b00535

Subject(s) - monoterpene , glycoside , chemistry , biotransformation , bursaphelenchus xylophilus , antibacterial activity , escherichia coli , bacteria , enzyme , biochemistry , organic chemistry , nematode , biology , ecology , genetics , gene

A promiscuous Bacillus glycosyltransferase (YjiC) was explored for the enzymatic synthesis of monoterpene O -glycosides in vitro and in vivo. YjiC converted seven monoterpenes into 41 different sugar-conjugated novel glycoside derivatives. The whole-cell biotransformation of the same set of monoterpenes exhibited robust enzyme activity to synthesize O -glucosyl derivatives from Escherichia coli . These newly synthesized selected monoterpene- O -glucosyl derivatives exhibited enhanced antibacterial activities against human pathogenic bacteria and antinematodal activities against pine wood nematode Bursaphelenchus xylophilus .

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