Macromolecular Probe Based on a NiII/TbIII Coordination Polymer for Sensitive Recognition of Human Serum Albumin (HSA) and MnO4–

Reported here are the design and fluorescence characters of a Ni II /Tb III polymer, [Tb 2 Ni 3 (HCAM) 6 (H 2 O) 12 ] n ( 1 ) (H 3 CAM = chelidamic acid). Under physiological conditions, the binding of biocompatible water soluble 1 to human serum albumin (HSA) was studied by spectroscopy techniques, which revealed that 1 could inherent the fluorescent light of HSA in a static quencher course and change the HSA second-level structure. The marked enhancement in 1 and its fluorescence intensity provide conclusive evidence that 1 can play the role of a "turn-on" sensor for recognition and detection of HSA in other biological interferents with a K sv value of 7.68 × 10 4 M -1 and a detection limit of 0.14 μM. Luminescence experiments show that 1 has high selectivity and sensitivity to MnO 4 - in other anions. Its quenching efficiency ( K sv ) is 5.54 × 10 3 M -1 , and the detection limit is 0.29 μM.