Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging | Zendy

Guillaume Thomas | Zendy; Julien Boudon | Zendy; Lionel Maurizi | Zendy; Mathieu Moreau | Zendy; Paul M. Walker | Zendy; Isabelle Séverin | Zendy; Alexandra Oudot | Zendy; Christine Goze | Zendy; Sophie Poty | Zendy; JeanMarc Vrigneaud | Zendy; Frédéric Demoisson | Zendy; Franck Denat | Zendy; François Brunotte | Zendy; Nadine Millot | Zendy

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Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging

Author(s) -

Guillaume Thomas,

Julien Boudon,

Lionel Maurizi,

Mathieu Moreau,

Paul M. Walker,

Isabelle Séverin,

Alexandra Oudot,

Christine Goze,

Sophie Poty,

JeanMarc Vrigneaud,

Frédéric Demoisson,

Franck Denat,

François Brunotte,

Nadine Millot

Publication year - 2019

Publication title -

acs omega

Language(s) - Uncategorized

Resource type - Journals

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b03283

Subject(s) - nanoparticle , materials science , ethylene glycol , positron emission tomography , magnetic resonance imaging , superparamagnetism , molecular imaging , peg ratio , nanotechnology , chemistry , nuclear medicine , organic chemistry , in vivo , magnetization , medicine , physics , microbiology and biotechnology , quantum mechanics , biology , magnetic field , radiology , finance , economics

Superparamagnetic iron oxide nanoparticles were developed as positron emission tomography (PET) and magnetic resonance imaging (MRI) bimodal imaging agents. These nanoparticles (NPs), with a specific nanoflower morphology, were first synthesized and simultaneously functionalized with 3,4-dihydroxy-l-phenylalanine (LDOPA) under continuous hydrothermal conditions. The resulting NPs exhibited a low hydrodynamic size of 90 ± 2 nm. The functional groups of LDOPA (-NH 2 and -COOH) were successfully used for the grafting of molecules of interest in a second step. The nanostructures were modified by poly(ethylene glycol) (PEG) and a new macrocyclic chelator MANOTA for further 64 Cu radiolabeling for PET imaging. The functionalized NPs showed promising bimodal (PET and MRI) imaging capability with high r 2 and r 2 * ( T 2 and T 2 * relaxivities) values and good stability. They were mainly uptaken from liver and kidneys. No cytotoxicity effect was observed. These NPs appear as a good candidate for bimodal tracers in PET/MRI.

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