Lectin-Recognizable MOF Glyconanoparticles: Supramolecular Glycosylation of ZIF-8 Nanocrystals by Sugar-Based Surfactants | Zendy

Rodrigo E. Giménez | Zendy; Esteban Piccinini | Zendy; Omar Azzaroni | Zendy; Matías Rafti | Zendy

Open Access

Lectin-Recognizable MOF Glyconanoparticles: Supramolecular Glycosylation of ZIF-8 Nanocrystals by Sugar-Based Surfactants

Author(s) -

Rodrigo E. Giménez,

Esteban Piccinini,

Omar Azzaroni,

Matías Rafti

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b03092

Subject(s) - lectin , glycosylation , supramolecular chemistry , nanocrystal , chemistry , sugar , nanotechnology , chemical engineering , materials science , biochemistry , organic chemistry , crystal structure , engineering

A strategy toward the integration of highly functional microporous materials, such as metal-organic frameworks (MOFs), in composites via biochemical recognition interactions is presented. Postsynthetic modification of zeolitic-imidazolate framework-8 MOF nanocrystals with a maltose-exposing biocompatible surfactant (the so-called "Glyco-MOFs") was performed to confer affinity toward lectin protein concanavalin A. The addition of small amounts of concanavalin A to the colloidal Glyco-MOF dispersion triggers the aggregation of these units into self-limited size supramolecular architectures directed by specific sugar-lectin binding interactions.

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