Benefits of Unconventional Methods in the Total Synthesis of Natural Products | Zendy

Tomáš Hudlický | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Benefits of Unconventional Methods in the Total Synthesis of Natural Products

Author(s) -

Tomáš Hudlický

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b02994

Subject(s) - enantioselective synthesis , total synthesis , context (archaeology) , chemistry , organic chemistry , pyrrolizidine , cyclopentene , combinatorial chemistry , biochemical engineering , catalysis , stereochemistry , engineering , biology , paleontology

This article provides a survey of four "unconventional" methods employed in the synthesis of natural products in the Hudlicky group. The utility of flash vacuum pyrolysis is highlighted by examples of many natural products attained via vinylcyclopropane-cyclopentene rearrangement and its heterocyclic variants. Preparative organic electrochemistry was used in oxidations and reductions with levels of selectivity unattainable by conventional methods. Yeast reduction of ketoesters was featured in the total synthesis of pyrrolizidine alkaloids. Finally, the use of toluene dioxygenase-mediated dihydroxylations in enantioselective synthesis of natural products concludes this presentation. Recently, synthesized targets in the period 2010-2019 are listed in the accompanying table. The results of research from the Hudlicky group are placed in appropriate context with the work of others, and a detailed guide to the current literature is provided.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research