Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies | Zendy

Martin Fries | Zendy; Meike Mertens | Zendy; Nico Teske | Zendy; Markus Kipp | Zendy; Cordian Beyer | Zendy; Thomas Willms | Zendy; Arto Valkonen | Zendy; Kari Rissanen | Zendy; Markus Albrecht | Zendy; Tim Clarner | Zendy

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Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies

Author(s) -

Martin Fries,

Meike Mertens,

Nico Teske,

Markus Kipp,

Cordian Beyer,

Thomas Willms,

Arto Valkonen,

Kari Rissanen,

Markus Albrecht,

Tim Clarner

Publication year - 2019

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b02523

Subject(s) - in vitro , in vivo , oligodendrocyte , multiple sclerosis , chemistry , superoxide dismutase , pathogenesis , derivative (finance) , microbiology and biotechnology , biochemistry , biophysics , pharmacology , biology , neuroscience , central nervous system , oxidative stress , myelin , immunology , genetics , economics , financial economics

The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone.

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