Open AccessDihydroquinoline Carbamate DQS1-02 as a Prodrug of a Potent Acetylcholinesterase Inhibitor for Alzheimer’s Disease Therapy: Multigram-Scale Synthesis, Mechanism Investigations, in Vitro Safety Pharmacology, and Preliminary in Vivo Toxicology Profile
Author(s) -
Florent Alix,
Vincent Gembus,
Laurent Coquet,
Marie HubertRoux,
Philippe Chan,
Lina Truong,
Muriel Sebban,
Gaël Coadou,
Hassan Oulyadi,
Cyril Papamicaël,
Vincent Levacher
Publication year - 2018
Publication title -
acs omega
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.779
H-Index - 40
ISSN - 2470-1343
DOI - 10.1021/acsomega.8b02121
Subject(s) - prodrug , acetylcholinesterase , adme , pharmacology , chemistry , in vivo , drug , carbamate , enzyme , in vitro , combinatorial chemistry , biochemistry , medicine , biology , microbiology and biotechnology
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