Ru(II)/Ir(III)-Catalyzed C–H Bond Activation/Annulation of Cyclic Amides with 1,3-Diketone-2-diazo Compounds: Facile Access to 8H-Isoquinolino[1,2-b]quinazolin-8-ones and Phthalazino[2,3-a]cinnoline-8,13-diones | Zendy

Panyuan Cai | Zendy; Enshen Zhang | Zendy; Yinsong Wu | Zendy; Taibei Fang | Zendy; Qianqian Li | Zendy; Chen Yang | Zendy; Jian Wang | Zendy; Yongjia Shang | Zendy

Open Access

Ru(II)/Ir(III)-Catalyzed C–H Bond Activation/Annulation of Cyclic Amides with 1,3-Diketone-2-diazo Compounds: Facile Access to 8H-Isoquinolino[1,2-b]quinazolin-8-ones and Phthalazino[2,3-a]cinnoline-8,13-diones

Author(s) -

Panyuan Cai,

Enshen Zhang,

Yinsong Wu,

Taibei Fang,

Qianqian Li,

Chen Yang,

Jian Wang,

Yongjia Shang

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b01930

Subject(s) - annulation , cinnoline , diazo , chemistry , carbene , catalysis , medicinal chemistry , hydrazine (antidepressant) , amide , stereochemistry , organic chemistry , chromatography

Efficient access to 8 H -isoquinolino[1,2- b ]quinazolin-8-ones and phthalazino[2,3- a ]cinnoline-8,13-diones through cyclic amide-directed Ru(II)/Ir(III)-catalyzed C-H bond activation, has been developed. Consecutive C-H bond activation, carbene insertion, and condensation annulation processes were realized, affording 8 H -isoquinolino[1,2- b ]quinazolin-8-one and phthalazino[2,3- a ]cinnoline-8,13-dione derivatives in good-to-excellent yields under mild conditions, with H 2 O and N 2 being generated as the only byproducts.

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