Ppm Cu Catalyst Enables tert-Alkylation Followed by C–H Cyclization To Synthesize Substituted Oxindoles | Zendy

Kohei Yoshinaga | Zendy; Naoya Tsubaki | Zendy; Yumi Murata | Zendy; Yushi Noda | Zendy; Takashi Nishikata | Zendy

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Ppm Cu Catalyst Enables tert-Alkylation Followed by C–H Cyclization To Synthesize Substituted Oxindoles

Author(s) -

Kohei Yoshinaga,

Naoya Tsubaki,

Yumi Murata,

Yushi Noda,

Takashi Nishikata

Publication year - 2018

Publication title -

acs omega

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b01397

Subject(s) - alkylation , catalysis , yield (engineering) , tandem , chemistry , medicinal chemistry , reaction conditions , combinatorial chemistry , organic chemistry , materials science , metallurgy , composite material

In this paper, we established highly efficient Cu-catalyzed tandem tert -alkylation C-H cyclization of α-bromocarbonyls and methacrylamides to produce substituted oxindoles. The maximum turnover number was up to 48 000 with reasonable yield. Although the catalyst loadings were very low, the reaction was not involving radical chain reaction. The resulting oxindoles were able to transform into aza-multicyclic compound via a reduction.

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