Zirconyl Clindamycinphosphate Antibiotic Nanocarriers for Targeting Intracellular Persisting Staphylococcus aureus | Zendy

Joachim G. Heck | Zendy; Katharina Rox | Zendy; Heinrich Lünsdorf | Zendy; Thorsten Lückerath | Zendy; Nicole Klaassen | Zendy; Eva Medina | Zendy; Oliver Goldmann | Zendy; Claus Feldmann | Zendy

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Zirconyl Clindamycinphosphate Antibiotic Nanocarriers for Targeting Intracellular Persisting Staphylococcus aureus

Author(s) -

Joachim G. Heck,

Katharina Rox,

Heinrich Lünsdorf,

Thorsten Lückerath,

Nicole Klaassen,

Eva Medina,

Oliver Goldmann,

Claus Feldmann

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b00637

Subject(s) - nanocarriers , staphylococcus aureus , antibiotics , microbiology and biotechnology , methicillin resistant staphylococcus aureus , chemistry , drug delivery , drug , medicine , pharmacology , biology , bacteria , organic chemistry , genetics

[ZrO] 2+ [CLP] 2- (CLP: clindamycinphosphate) inorganic-organic hybrid nanoparticles (IOH-NPs) represent a novel strategy to treat persisting, recurrent infections with multiresistant Staphylococcus aureus . [ZrO] 2+ [CLP] 2- is prepared in water and contains the approved antibiotic with unprecedented high load (82 wt % CLP per nanoparticle). The IOH-NPs result in 70-150-times higher antibiotic concentrations at difficult-to-reach infection sites, offering new options for improved drug delivery for chronic and difficult-to-treat infections.

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