Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher | Zendy

Benjamin K. Liebov | Zendy; Alejandro D. Arroyo | Zendy; Natalia I. Rubtsova | Zendy; Sofya A. Osharovich | Zendy; Edward J. Delikatny | Zendy; Anatoliy V. Popov | Zendy

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Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher

Author(s) -

Benjamin K. Liebov,

Alejandro D. Arroyo,

Natalia I. Rubtsova,

Sofya A. Osharovich,

Edward J. Delikatny,

Anatoliy V. Popov

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b00635

Subject(s) - phosphatidylethanolamine , fluorescence , moiety , quenching (fluorescence) , chemistry , phosphatidylcholine , biophysics , biochemistry , phospholipid , stereochemistry , biology , physics , quantum mechanics , membrane

The near-infrared fluorescent activatable smart probe Pyro-phosphatidylethanolamine (PtdEtn)-QSY was synthesized and observed to selectively fluoresce in the presence of phosphatidylcholine-specific phospholipase C (PC-PLC). PC-PLC is an important biological target as it is known to be upregulated in a variety of cancers, including triple negative breast cancer. Pyro-PtdEtn-QSY features a QSY21 quenching moiety instead of the Black Hole Quencher-3 (BHQ-3) used previously because the latter contains an azo bond, which could lead to biological instability.

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