Synthesis and Preliminary Antimicrobial Analysis of Isatin–Ferrocene and Isatin–Ferrocenyl Chalcone Conjugates | Zendy

Amandeep Singh | Zendy; Grant Fong | Zendy; Jenny Liu | Zendy; Yun-Hsuan Wu | Zendy; Kevin Chang | Zendy; William Park | Zendy; JiHwan Kim | Zendy; Christina Tam | Zendy; Luisa W. Cheng | Zendy; Kirkwood M. Land | Zendy; Vipan Kumar | Zendy

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Synthesis and Preliminary Antimicrobial Analysis of Isatin–Ferrocene and Isatin–Ferrocenyl Chalcone Conjugates

Author(s) -

Amandeep Singh,

Grant Fong,

Jenny Liu,

Yun-Hsuan Wu,

Kevin Chang,

William Park,

JiHwan Kim,

Christina Tam,

Luisa W. Cheng,

Kirkwood M. Land,

Vipan Kumar

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b00553

Subject(s) - isatin , chalcone , ferrocene , antimicrobial , chemistry , triazole , combinatorial chemistry , conjugate , stereochemistry , biochemistry , organic chemistry , mathematical analysis , mathematics , electrode , electrochemistry

In this study, we outline the synthesis of isatin-ferrocenyl chalcone and 1 H -1,2,3-triazole-tethered isatin-ferrocene conjugates along with their antimicrobial evaluation against the human mucosal pathogen Trichomonas vaginalis . The introduction of a triazole ring among the synthesized conjugates improved the activity profiles with most of the compounds in the library, exhibiting 100% growth inhibition in a preliminary susceptibility screen at 100 μM. IC 50 determination of the most potent compounds in the set revealed an inhibitory range between 2 and 13 μM. Normal flora microbiome are unaffected by these compounds, suggesting that these may be new chemical scaffolds for the discovery of new drugs against trichomonad infections.

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