Spontaneous Biomacromolecule Absorption and Long-Term Release by Graphene Oxide | Zendy

Junjira Tanum | Zendy; Jiwoong Heo | Zendy; Jinkee Hong | Zendy

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Spontaneous Biomacromolecule Absorption and Long-Term Release by Graphene Oxide

Author(s) -

Junjira Tanum,

Jiwoong Heo,

Jinkee Hong

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b00537

Subject(s) - graphene , materials science , oxide , adsorption , fabrication , layer (electronics) , macromolecule , nanotechnology , chemical engineering , absorption (acoustics) , layer by layer , composite material , chemistry , organic chemistry , medicine , biochemistry , alternative medicine , pathology , engineering , metallurgy

Biomacromolecule loading is the popular research in the biomedical field. To control the loading amount and releasing profile, various materials and fabrication techniques were developed. In this study, layer-by-layer assembly of multilayer films between collagen (Col) and graphene oxide (GO) was used to control the release of the loading molecule. By mixing GO into the system, ovalbumin (OVA) can be spontaneously adsorbed onto the GO sheet (denoted as GO/OVA) via the hydrophobic interaction. Two kinds of multilayer films (Col/GO/OVA and Col/GO/OVA) were fabricated. The thickness growth curve, quantitative of each layer adsorption, film morphology, stability, cell viability, and OVA release from multilayer films were investigated. The result has shown excellent film stability, macromolecule loading, and sustained release because of GO ability.

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