Synthesis of an Alleged Byproduct Precursor in Iodixanol Preparation | Zendy

Marianne B. Haarr | Zendy; Emil Lindbäck | Zendy; Torfinn Håland | Zendy; Magne O. Sydnes | Zendy

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Synthesis of an Alleged Byproduct Precursor in Iodixanol Preparation

Author(s) -

Marianne B. Haarr,

Emil Lindbäck,

Torfinn Håland,

Magne O. Sydnes

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b00411

Subject(s) - iodixanol , yield (engineering) , epoxide , amide , chemistry , nuclear chemistry , organic chemistry , materials science , contrast medium , catalysis , medicine , metallurgy , radiology

N 1 , N 3 -Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-( N -(oxiran-2-ylmethyl)acetamido)isophthalamide ( 1 ), the alleged precursor of several minor byproducts formed when the X-ray contrast agent iodixanol is synthesized from 5-acetamido- N 1 , N 3 -bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide ( 2 ), has been successfully prepared with an overall yield of 25%. Epoxide 1 enabled the confirmation of its presence in the reaction mixture during the preparation of iodixanol when amide 2 was used as the starting material.

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