Encapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes | Zendy

Sieun Chae | Zendy; Dahee Kim | Zendy; Kyungjin Lee | Zendy; Dasol Lee | Zendy; YoungO Kim | Zendy; Yong Chae Jung | Zendy; Sang Dal Rhee | Zendy; Kwang Rok Kim | Zendy; JeongO Lee | Zendy; Sunjoo Ahn | Zendy; Byumseok Koh | Zendy

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Encapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes

Author(s) -

Sieun Chae,

Dahee Kim,

Kyungjin Lee,

Dasol Lee,

YoungO Kim,

Yong Chae Jung,

Sang Dal Rhee,

Kwang Rok Kim,

JeongO Lee,

Sunjoo Ahn,

Byumseok Koh

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b00399

Subject(s) - camptothecin , carbon nanotube , drug delivery , chemistry , aqueous solution , nanotechnology , topoisomerase , materials science , organic chemistry , enzyme

The topoisomerase I inhibitors SN-38 and camptothecin (CPT) have shown potent anticancer activity, but water insolubility and metabolic instability limits their clinical application. Utilizing carbon nanotubes as a protective shell for water-insoluble SN-38 and CPT while maintaining compatibility with aqueous media via a carboxylic acid-functionalized surface can thus be a strategy to overcome this limitation. Through hydrophobic-hydrophobic interactions, SN-38 and CPT were successfully encapsulated in carboxylic acid functionalized single-walled carbon nanotubes and dispersed in water. The resulting cell proliferation inhibition and drug distribution profile inside the cells suggest that these drug-encapsulated carbon nanotubes can serve as a promising delivery strategy for water-insoluble anticancer drugs.

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