I2-Catalyzed Oxidative Cross-Coupling Reaction of Methyl Ketones and 2-(2-Aminophenyl) Benzimidazole: Facile Access to Benzimidazo[1,2-c]quinazoline | Zendy

Sethurajan Ambethkar | Zendy; Mariappan Kalaiselvi | Zendy; Jaganathan Ramamoorthy | Zendy; Vediappen Padmini | Zendy

Open Access

I₂-Catalyzed Oxidative Cross-Coupling Reaction of Methyl Ketones and 2-(2-Aminophenyl) Benzimidazole: Facile Access to Benzimidazo[1,2-c]quinazoline

Author(s) -

Sethurajan Ambethkar,

Mariappan Kalaiselvi,

Jaganathan Ramamoorthy,

Vediappen Padmini

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.8b00067

Subject(s) - benzimidazole , catalysis , quinazoline , chemistry , aniline , oxidative phosphorylation , coupling reaction , medicinal chemistry , iodine , condensation , combinatorial chemistry , organic chemistry , biochemistry , physics , thermodynamics

A general and efficient iodine-catalyzed metal-free oxidative cross-coupling reaction of methyl ketones with 2-(1 H -benzo[ d ]imidazol-2-yl)aniline has been established. This is a new synthetic strategy for the synthesis of benzimidazo[1,2- c ]quinazoline derivatives involving C(sp 3 )-H oxidation, condensation, and cyclization processes.

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