Empowering Transition-Metal-Free Cascade Protocol for the Green Synthesis of Biaryls and Alkynes | Zendy

Preet Kamal Walia | Zendy; M. Kumar | Zendy; Vandana Bhalla | Zendy

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Empowering Transition-Metal-Free Cascade Protocol for the Green Synthesis of Biaryls and Alkynes

Author(s) -

Preet Kamal Walia,

M. Kumar,

Vandana Bhalla

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b02014

Subject(s) - aryl , cascade , combinatorial chemistry , aqueous medium , chemistry , transition metal , transformation (genetics) , molecule , cascade reaction , aqueous solution , catalysis , organic chemistry , alkyl , chromatography , biochemistry , gene

The work being presented in this paper demonstrates the simple and efficient "transition-metal-free" and "light-mediated" synthetic protocol for the synthesis of aryl iodides/biaryls/alkynes from aryl bromides. Under ultraviolet irradiation and in basic aqueous media, aryl bromides undergo transformation into aryl iodides which efficiently couple via a cascade reaction with a wide range of terminal alkynes/unactivated arenes to generate target molecules under green conditions.

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