Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation | Zendy

Paresh R. Athawale | Zendy; Gorakhnath R. Jachak | Zendy; Anurag Shukla | Zendy; Dhanasekaran Shanmugam | Zendy; D. Srinivasa Reddy | Zendy

Open Access

Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation

Author(s) -

Paresh R. Athawale,

Gorakhnath R. Jachak,

Anurag Shukla,

Dhanasekaran Shanmugam,

D. Srinivasa Reddy

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b01920

Subject(s) - natural product , polyketide , stereochemistry , combinatorial chemistry , chemistry , peptide , biology , computational biology , biochemistry , biosynthesis , gene

To identify novel antitrypanosomal agents based on Janadolide, a potent macrocyclic polyketide-peptide hybrid, a macrolactonization strategy was explored. We prepared des- tert -butyl Janadolide and evaluated its antitrypanosomal activity. Our findings suggest that the tert -butyl group is necessary for the desired bioactivity.

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