Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation of para-Quinone Methides: Facile Access to Diarylmethyl Sulfones | Zendy

Teng Liu | Zendy; Jianjun Liu | Zendy; ShuBiao Xia | Zendy; Jie Meng | Zendy; Xianfu Shen | Zendy; Xiufang Zhu | Zendy; WenChang Chen | Zendy; Chengke Sun | Zendy; Feixiang Cheng | Zendy

Open Access

Catalyst-Free 1,6-Conjugate Addition/Aromatization/Sulfonylation of para-Quinone Methides: Facile Access to Diarylmethyl Sulfones

Author(s) -

Teng Liu,

Jianjun Liu,

ShuBiao Xia,

Jie Meng,

Xianfu Shen,

Xiufang Zhu,

WenChang Chen,

Chengke Sun,

Feixiang Cheng

Publication year - 2018

Publication title -

acs omega

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b01745

Subject(s) - aromatization , conjugate , catalysis , regioselectivity , chemistry , organic chemistry , mathematics , mathematical analysis

An efficient, catalyst-free strategy to construct diarylmethyl sulfones via 1,6-conjugate addition/aromatization/sulfonylation reaction of para -quinone methides with sulfonyl hydrazides under mild and environmentally benign conditions has been developed. The established protocol provided a highly chemo- and regioselectivity synthesis of a diverse array of novel diarylmethyl sulfones with excellent yields, and the reaction could be scaled up.

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