Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents | Zendy

Francis Hane | Zendy; P. U. Ashvin Iresh Fernando | Zendy; Braedan R. J. Prete | Zendy; Brianna Peloquin | Zendy; Scott Karas | Zendy; Sauradip Chaudhuri | Zendy; Simrun Chahal | Zendy; Yurii Shepelytskyi | Zendy; Alanna Wade | Zendy; Tao Li | Zendy; Brenton DeBoef | Zendy; Mitchell S. Albert | Zendy

Open Access

Cyclodextrin-Based Pseudorotaxanes: Easily Conjugatable Scaffolds for Synthesizing Hyperpolarized Xenon-129 Magnetic Resonance Imaging Agents

Author(s) -

Francis Hane,

P. U. Ashvin Iresh Fernando,

Braedan R. J. Prete,

Brianna Peloquin,

Scott Karas,

Sauradip Chaudhuri,

Simrun Chahal,

Yurii Shepelytskyi,

Alanna Wade,

Tao Li,

Brenton DeBoef,

Mitchell S. Albert

Publication year - 2018

Publication title -

acs omega

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.779

H-Index - 40

ISSN - 2470-1343

DOI - 10.1021/acsomega.7b01744

Subject(s) - xenon , chemistry , nuclear magnetic resonance spectroscopy , nuclear magnetic resonance , nanotechnology , materials science , organic chemistry , physics

Hyperpolarized (HP) xenon-129 (Xe) magnetic resonance (MR) imaging has the potential to detect biological analytes with high sensitivity and high resolution when coupled with xenon-encapsulating molecular probes. Despite the development of numerous HP Xe probes, one of the challenges that has hampered the translation of these agents from in vitro demonstration to in vivo testing is the difficulty in synthesizing the Xe-encapsulating cage molecule. In this study, we demonstrate that a pseudorotaxane, based on a γ-cyclodextrin macrocycle, is easily synthesized in one step and is detectable using HyperCEST-enhanced 129 Xe MR spectroscopy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research